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CELINE DERMARDIROSSIAN, PH.D.
Professor
Céline DerMardirossian received her Ph.D. in Biochemistry from the University of Paris Orsay XI, France and completed her post-doctoral studies in the Department of Immunology and Microbiology in Prof. Gary M. Bokoch at The Scripps Research Institute, La Jolla, CA. As an Associate Professor at The Scripps Research Institute in the Molecular and Medicine Department, her work was focused on deciphering the molecular mechanisms that regulate the spatio-temporal activation of GTPases for efficient cell locomotion. This information is critical to our understanding of the mechanisms underlying normal physiological function and the consequences of dysregulation under pathological conditions as cancer. Recently, Dr. DerMardirossian joined SDBRI as a Professor, she is also an Adjunct Associate Professor in the Molecular and Medicine Department at The Scripps Research Institute. Ongoing projects in the lab are the analysis of the role of RhoGTPases, their regulators GEFs and GAPs, and their new binding partners identified in the lab in regulating cell migration and invasion to design new strategies to control the aberrant activation of RhoGTPases in cancer.
Experimental approaches used in her lab include techniques of biochemistry, state-of-the-art microscopy, high throughput screening, and xenograft mouse studies.
PUBLICATIONS
DerMardirossian C, Schnelzer A, Bokoch GM. Mol Cell. 2004 Jul 2;15(1):117-27. PDF
DerMardirossian, C., Rocklin, G., Seo, J. Y., & Bokoch, G. M. (2006). Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Molecular biology of the cell, 17(11), 4760-8. PDF
Bielek, H., Anselmo, A., & Dermardirossian, C. (2009). Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI. Cellular signalling, 21(12), 1974-83. PDF
Delorme-Walker, V., Seo, J. Y., Gohla, A., Fowler, B., Bohl, B., & DerMardirossian, C. (2015). Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels. Proceedings of the National Academy of Sciences of the United States of America, 112(37), E5150-9. PDF
Hodgson, L., Spiering, D., Sabouri-Ghomi, M., Dagliyan, O., DerMardirossian, C., Danuser, G., & Hahn, K. M. (2016). FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nature chemical biology, 12(10), 802-809. PDF
Pathak, R., Delorme-Walker, V. D., Howell, M. C., Anselmo, A. N., White, M. A., Bokoch, G. M., & Dermardirossian, C. (2012). The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic. Developmental cell, 23(2), 397-411. PDF
Pathak, R., & Dermardirossian, C. (2013). GEF-H1: orchestrating the interplay between cytoskeleton and vesicle trafficking. Small GTPases, 4(3), 174-9. PDF
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